In a discussion of the activities of MI5's Port Control section during the First World War, Christopher Andrew mentions German musings about using biological weapons against British civilians:
The most novel as well as the most sinister form of wartime sabotage attempted by Sektion P was biological warfare. At least one of its scientists in 1916 devised a scheme to start a plague epidemic in Britain, either by infecting rats or, more improbably, by dropping plague bacilli cultures from Zeppelins over ports. The Prusso-German General Staff, however, vetoed bacteriological warfare against humans as totally contrary to international law (the Hague Laws of Warfare).
But he doesn't provide any references. Is this plausible?
The British War Cabinet considered 'The possible Spread of Epidemics by dropping Germs from the Air' during its meeting on 9 February 1917. It accepted the advice from experts from the Royal Society, the Army Medical Service and the Local Government Board that the possibility was remote, and that any outbreak would be easily contained. Consequently Cabinet decided that 'no further action was required'. The expert reports themselves are quite interesting. That from Dr Arthur Newsholme, the chief medical officer of the Local Government Board, notes press reports of 'poisoned sweets and garlic saturated with garlic being stated to have been dropped at Constanza [Romania] from enemy aeroplanes'. Closer to home, the Board itself received a letter claiming that 'according to information "from a reliable source," infected sweetmeats had been dropped over Sheffield'. But, Newsholme added, no evidence had been produced in either case.
None of this relates to bubonic plague, however. And in Martin Hugh-Jones's summary of known (that is, by the British) wartime German biological warfare plans, plague is not mentioned. Most of the actual biological warfare activity by Germany during the First World War was directed towards anthrax and glanders, for use against horses, sheep and cattle. Nor does Hugh-Jones know of German wartime proposals to spread disease from the air (as opposed to proposals after the war, which is the focus of his article).
But bubonic plague can be weaponised and deployed from the air. Japan's Unit 731 proved that in China in 1940 and 1941, not only in controlled experiments but in field trials. And by field trials I mean, of course, bombing civilian areas with bubonic plague. There were at least four separate attacks, involving at most a handful of Japanese aircraft: Chuhsien, 4 October 1940; Ningpo, 27 October 1940; Kinhwa, 28 November 1940; and Changteh, 4 November 1941. The plague was not dropped in bombs but usually by way of fleas and grain; in two cases plague bacilli were detected by local hospitals. Only in Kinhwa did no outbreak of plague follow; a hundred people died in Ningpo alone.
So it does seem possible that German scientists considered using Zeppelins to rain black death upon Britain, and that it may even have worked. The British experts may have underestimated the potential of this form of aerial attack; and the psychological impact might have been far greater than the medical one. Then again, the great influenza pandemic in 1918 didn't disrupt the war to any great extent, and it killed far more people than any plague would have done. So the War Cabinet's lack of concern was justified, in the non-event.