A tweet from William J. Turkel alerted me to the possibility of using 18th century-style fonts in LaTeX. The most noticeable difference from modern typesetting is the long s, but there are different ligatures too. There are a number of ways to do it but the easiest way is with the inbuilt Kepler Fonts package. (The Fell Types are far prettier, but look difficult, or at least tedious, to install. Font management is one of LaTeX's biggest weaknesses.) Just insert the following in your preamble and you're done:
Well, almost. This simply replaces every s with a long s, which is not right. Most importantly, long s is generally not used at the end of a word, so you need to replace these with 's='. Here's what the first paragraph of my thesis looks like when done this way:
I wish I'd known about this before submitting it.